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What Has T.R. Knight Been Doing Since Leaving Grey's Anatomy?

"Grey's Anatomy" fans have seen their share of turnover at Grey Sloan Memorial Hospital throughout the show's 19 seasons on ABC. The show has said goodbye to such memorable characters as Dr. Cristina Yang (Sandra Oh), Dr. Callie Torres (Sara Ramírez), Dr. Derek Shepherd (Patrick Dempsey), and most recently, Dr. Jackson Avery (Jesse Williams). But many longtime fans will always remember the lovable Dr. George O'Malley, played by T.R. Knight. Dr. O'Malley, whose eventual death was arguably the show's most upsetting demise, is a member of the first round of surgical interns, which includes Dr. Meredith Grey (Ellen Pompeo). O'Malley charmed his way into the hearts of fans during the show's first five seasons. But his storyline comes to a tragic end in Season 5, Episode 24, "Now or Never," which finds the team at Grey Sloan trying to save a John Doe who was hit by a bus. The patient is identified as George, who ultimately dies from his injuries.

Following a decade-plus hiatus from the show, Knight made a grand return in Season 17, Episode 4, "You'll Never Walk Alone." George appears to Meredith in a dream that also includes a guest appearance from Derek. While fans may miss the days of seeing Dr. O'Malley saving lives, they currently can catch Knight co-starring in another small-screen hit.

Knight is finding fresh success on a well-known streaming platform

T.R. Knight is back on television as Davey Bowden in the hit HBO Max comedy-drama series "The Flight Attendant," based on the popular novel written by Chris Bohjalian. Season 1 of the show follows Davey's sister Cassie Bowden (Kaley Cuoco), a flight attendant who finds herself in the middle of a murder mystery following a night with a handsome stranger who dies.

Knight told ET Canada that while the book was the basis for Season 1, Season 2 is an entirely new adventure, which includes Cassie solving mysteries for the CIA. Meanwhile, Davey is helping his sister process past mistakes while facing his tough relationship with their father. It causes conflict between Davey and Cassie. "I love that real difficult relationship that they have," he told ET Canada. "It's just fascinating how two people raised in the same family with a lot of damage are so diametrically opposed in so many ways ... If you would just read about this scenario, you would think, 'Oh, at least they have each other,' but they clash so much. And I think it's just exciting to play."

"The Flight Attendant" is currently streaming on HBO Max. Anyone hoping to see more of Davey and Cassie's sibling bond may have a long wait, as Cuoco shared her thoughts about Season 3 that were the last thing fans wanted to hear