The Sisters Brothers Trailer: Joaquin Phoenix, John C. Reilly Are Sibling Assassins

Ever heard of the Sisters Brothers, dear reader? Well, it's time to get acquainted. 

Annapurna Pictures has dropped the first trailer for The Sisters Brothers, the Joaquin Phoenix and John C. Reilly-led flick from director Jacques Audiard. 

Set to a variation of the absolute banger of a song "Tainted Love" by Soft Cell, the trailer zooms in on the darkly hilarious elements seen in the film's source material, Patrick Dewitt's celebrated novel of the same name, and introduces viewers to sibling hired guns Eli (Reilly) and Charlie Sisters (Phoenix). While Eli is fixing to retire his weapons and "open a store," Charlie is less enthused about the prospect of giving up their gigs as assassins. 

The year is 1851, and the pair soon find themselves tasked with a major mission: travel from Oregon City to San Francisco, working with their accomplice (played by Jake Gyllenhaal) to locate a prospector and chemist (The Night Of star Riz Ahmed) who has stolen from their boss. Their plan gets turned inside out when they learn what the chemist has really been concocting all this time: a formula for finding gold in the river, making digging it up a heck of a lot easier. 

Watch the full trailer above. 

The Sisters Brothers serves as the English-language feature debut from director Audiard, who is known for A Prophet, Rust and Bone, and Dheepan, which took home the coveted Palme d'Or at the Cannes Film Festival in 2015. Audiard co-wrote the script with his longtime collaborator Thomas Bidegain, who, funnily enough, made his directorial debut in 2015 with the Reilly-starring flick Les Cowboys. 

Rutger Hauer, Carol Kane, and Rebecca Root also star in The Sisters Brothers, due out this fall. Annapurna hasn't yet announced an official debut date.