Fans of “That 70s Show” enjoyed watching Mila Kunis’ Jackie Burkhart gripe at her dimwitted boyfriend, Michael Kelso, played by Ashton Kutcher but what they may not know is that Kunis' on-screen kisses with Kutcher were her first kisses in real life. First kisses can be awkward but this one led to marriage in 2015.

HBO’s vampire drama “True Blood” was wildly popular and racked up millions of followers in large part due to the undeniable chemistry between Anna Paquin’s Sookie Stackhouse and Stephen Moyer’s Bill Compton. Their on-screen chemistry spilled over to their real lives as they tied the knot in 2010 and welcomed twins in 2012.

Handsome movie star Michael Fassbender has a history of hooking up with his co-stars but when he worked opposite beauty Alicia Vikander on “The Light Between Oceans,” he was so smitten that his serial dating came to a halt. In 2017 this talented acting duo tied the knot in a secret ceremony in Ibiza.

Tracy Pollan and Michael J. Fox shared an iconic scene in NBC’s ‘80s hit family sitcom “Family Ties” where the actors kissed and danced to Billy Vera's bittersweet song "At This Moment." Their chemistry was obvious and after reconnecting in 1987’s gritty drama “Bright Lights, Big City” they got hitched the following year and have been together ever since.

2012’s romantic drama “The Words” may not be one of the most memorable movies of the decade, but the on-screen romance between Bradley Cooper and Zoe Saldana jumped off the screen. The chemistry was so real that they ended up dating for about a year after the film, before calling it quits.