As weird as it might've been even at the time, "Crackdown" isn't actually the weirdest transformation that the Punisher has ever had, and believe it or not, neither is the time that he was infamously resurrected as an angel who was tasked with shooting demons with magical ghost guns. No, the weirdest thing that ever happened to the Punisher was that time he was resurrected as a Frankenstein, and it's hard to imagine anything ever beating that.
The setup for this one was actually really great. In 2009, Marvel had only recently reintroduced the Punisher to the Marvel Universe proper, after a decade of keeping him contained in the mature readers MAX titles. The thing is, this also happened during the "Dark Reign" era, when notorious supervillain Norman Osborn—better known to Spider-Man fans as the Green Goblin—was put in charge of national security, replacing S.H.I.E.L.D. with the sinister H.A.M.M.E.R. Obviously, an unrepentant murderer in a position of power made for a tempting target, and Frank quickly set his sights on taking Osborn down, once and for all.
Unfortunately, at the end of the day, the Punisher is just a guy with a gun—okay, a lot of guns—and Osborn was surrounded by his own team of dark Avengers, who quickly moved to end the threat to their boss. Daken, the son of Wolverine, ended up chopping Frank to pieces and throwing his body into a sewer…where it was eventually found and stitched back together by Morbius the Living Vampire, who brought him back to life with the power of the mystical Bloodstone so that he could protect a secret city of monsters underneath Manhattan.
In the Marvel Universe of the comics, that's actually a pretty logical course of action. The shows, on the other hand, are probably not in a hurry to include Werewolf by Night and N'Kantu the Living Mummy, even if Jon Bernthal would look pretty great as a Frankenstein.