According to legend (and Patrick Stewart), during a press conference announcing the casting for Star Trek: The Next Generation, a reporter grilled Gene Roddenberry about Stewart's casting. Specifically the reporter asked Roddenberry how audiences were supposed to believe a bald man could command the USS Enterprise because "surely by the 24th Century someone would have found a cure for male pattern baldness." Without missing a beat, Roddenberry shot back, "By the 24th Century, no one will care."
A strange sentiment considering that, early in production, Roddenberry actively fought against Stewart's casting precisely because he was bald and also English. In a documentary about the tumultuous casting process for The Next Generation, it's noted that Roddenberry intensely disliked that idea of a bald Englishman playing "the next Captain Kirk." As a result, when Stewart did eventually land an audition, he was forced to do so in a wig that didn't fit properly, which was specially shipped from London to L.A.
After hearing Stewart read lines in the wig, Roddenberry suddenly changed his mind and had Stewart take it off, sagely explaining to an incredulous producer present that "hair doesn't mean anything in the 25th Century."